Bells HardingstoneSouth Carolina is home to some of the most relaxing and rejuvenating destinations in the United States, offering an ideal mix of luxury, nature, and Southern charm. The top spa & wellness resorts in South Carolina provide travelers with exceptional treatments, breathtaking coastal or mountain views, and personalized wellness experiences. From oceanfront sanctuaries on Hilton Head Island to historic retreats in Charleston, these resorts are designed to restore balance, calm the mind, and refresh the spirit in complete comfort.
Top 35 Spa and Wellness Resorts in South Carolina
1. The Sanctuary at Kiawah Island Golf Resort – Kiawah Island, SC
The Sanctuary at Kiawah Island Golf Resort is one of the most luxurious spa & wellness resorts in South Carolina. It offers ocean-inspired therapies, world-class massages, and rejuvenating facials in a serene coastal setting. Surrounded by natural beauty, the spa promotes total relaxation with hydrotherapy and aromatherapy sessions. Guests can also enjoy fine dining, ocean views, and top-rated golf courses, making it a perfect destination for health, beauty, and tranquility along the Atlantic coast.
2. The Spa at Palmetto Bluff – Bluffton, SC
The Spa at Palmetto Bluff is a premier retreat among spa & wellness resorts in South Carolina. Located in a lush riverside setting, it provides a holistic wellness experience with nature-based treatments, body wraps, and yoga sessions. Its personalized therapies focus on balance and relaxation, complemented by luxury accommodations and organic cuisine. This resort blends Southern charm with modern wellness, offering guests an unforgettable escape that renews the mind, body, and spirit in every sense
3. Belmond Charleston Place – Charleston, SC
Belmond Charleston Place stands out among spa & wellness resorts in South Carolina for its timeless luxury and rejuvenating spa experiences. The spa features a wide range of massages, skincare, and body treatments designed for deep relaxation. Guests also enjoy rooftop pools, steam rooms, and a modern fitness center. Located in the heart of historic Charleston, it perfectly combines urban elegance with peaceful wellness, offering a refreshing balance between indulgence, culture, and complete relaxation.
4. The Westin Hilton Head Island Resort & Spa – Hilton Head Island, SC
The Westin Hilton Head Island Resort & Spa is one of the finest spa & wellness resorts in South Carolina. Its Heavenly Spa offers restorative massages, facials, and wellness programs that focus on inner balance and rejuvenation. The oceanfront location enhances relaxation with calming sea views and fresh air. Guests can participate in fitness classes or yoga sessions, ensuring total renewal. The resort’s serene atmosphere and excellent service make it a top wellness destination.
5. Wild Dunes Resort – Isle of Palms, SC
Wild Dunes Resort is a top-rated destination among spa & wellness resorts in South Carolina, combining luxury, wellness, and coastal beauty. Its spa provides personalized treatments such as deep-tissue massages, facials, and body scrubs designed for relaxation and renewal. Guests enjoy oceanfront accommodations, yoga classes, and wellness packages that cater to both couples and solo travelers. The peaceful beachside environment and professional therapists make it ideal for anyone seeking a full wellness retreat experience.
6. Omni Hilton Head Oceanfront Resort – Hilton Head Island, SC
Omni Hilton Head Oceanfront Resort ranks high among spa & wellness resorts in South Carolina for its Ocean Tides Spa, offering customized massages, exfoliating treatments, and body wraps. Overlooking the Atlantic, it promotes total well-being with fitness classes, saunas, and yoga. Guests can also enjoy the resort’s fine dining and oceanfront suites. Its focus on holistic healing and relaxation makes it a haven for travelers seeking serenity in one of the most beautiful beach destinations.
7. Hotel Domestique – Travelers Rest, SC
Hotel Domestique is a boutique wellness haven that stands out among spa & wellness resorts in South Carolina. Located near the Blue Ridge Mountains, it provides personalized fitness training, cycling tours, yoga, and massage therapies that focus on balance and revitalization. Guests enjoy farm-to-table cuisine and breathtaking scenery that encourages peace and mindfulness. The combination of luxury, natural surroundings, and expert wellness programs makes it perfect for guests looking for a refined rejuvenating escape.
8. Wentworth Mansion – Charleston, SC
Wentworth Mansion is an exclusive retreat among spa & wellness resorts in South Carolina. The Spa at Wentworth offers a range of therapeutic treatments including aromatherapy massages, facials, and body therapies. Housed in a historic mansion, it creates an elegant yet intimate atmosphere ideal for deep relaxation. Guests can unwind while enjoying Charleston’s charm, excellent dining, and warm hospitality. The serene setting and personalized care make it a perfect choice for relaxation and indulgence.
9. The Inn & Club at Harbour Town – Hilton Head Island, SC
The Inn & Club at Harbour Town ranks among the most refined spa & wellness resorts in South Carolina. Its world-class spa features body treatments, facials, and rejuvenating massages. Guests have access to golf courses, tennis courts, and pristine beaches that add to the experience. The resort’s combination of Southern hospitality, luxurious amenities, and calming atmosphere ensures a balanced and peaceful stay, making it a top destination for both leisure and wellness enthusiasts.
10. The Dewberry Charleston – Charleston, SC
The Dewberry Charleston is one of the most stylish spa & wellness resorts in South Carolina, blending vintage sophistication with modern comfort. The spa offers botanical-based therapies, massages, and skincare treatments that refresh and restore. Guests can enjoy serene spaces, yoga programs, and fine dining that enhance the overall wellness journey. Located in downtown Charleston, it provides a peaceful retreat amid city life, ideal for travelers seeking luxury, culture, and mindful rejuvenation.
11. The Red Horse Inn – Landrum, SC
The Red Horse Inn stands out among spa & wellness resorts in South Carolina for its romantic countryside setting and private in-room spa treatments. Nestled in the foothills of the Blue Ridge Mountains, it offers couples massages, wine tastings, and serene garden walks. Guests enjoy privacy, peace, and breathtaking mountain views. The relaxing atmosphere, charming accommodations, and personalized services make it perfect for romantic getaways or a quiet wellness retreat surrounded by nature.
12. Charleston Harbor Resort & Marina – Mount Pleasant, SC
Charleston Harbor Resort & Marina is a coastal gem among spa & wellness resorts in South Carolina. Its Estuary Spa provides full-body massages, facials, and wellness packages using natural products. Guests can enjoy waterfront dining, fitness classes, and stunning harbor views. The combination of nautical charm, modern luxury, and holistic treatments ensures total relaxation. Its proximity to downtown Charleston also allows visitors to enjoy both cultural exploration and serene rejuvenation in one destination.
13. Sonesta Resort Hilton Head Island – Hilton Head Island, SC
Sonesta Resort Hilton Head Island is among the most popular spa & wellness resorts in South Carolina. The Arum Spa offers therapeutic massages, facials, and relaxation rituals inspired by the ocean. Guests can unwind in tropical surroundings, enjoy beach walks, or join yoga sessions. With spacious rooms, great dining, and personalized care, it promotes health and happiness. This resort’s focus on tranquility, beauty, and natural healing makes it ideal for wellness travelers year-round.
14. The Restoration Hotel – Charleston, SC
The Restoration Hotel is a boutique sanctuary among spa & wellness resorts in South Carolina. Its Amethyst Spa provides luxurious treatments using crystals, aromatherapy, and herbal remedies for balance and rejuvenation. Guests can enjoy rooftop yoga, meditation sessions, and artisan dining experiences. Located in the heart of Charleston, it seamlessly combines relaxation with urban charm. The hotel’s focus on holistic well-being and personalized experiences makes it a favorite destination for luxury wellness seekers.
15. North Beach Plantation Resort – North Myrtle Beach, SC
North Beach Plantation Resort is a coastal paradise among spa & wellness resorts in South Carolina. The Cinzia Spa offers massages, facials, body wraps, and wellness programs in a calming environment. Guests enjoy access to pools, fitness centers, and the beach, creating a complete relaxation experience. The blend of luxury amenities, professional therapists, and oceanfront tranquility makes it an exceptional choice for those seeking rejuvenation, beauty, and serenity along South Carolina’s coastline.
16. Grande Dunes Resort – Myrtle Beach, SC
Grande Dunes Resort is one of the most admired spa & wellness resorts in South Carolina, offering top-tier spa treatments and oceanfront relaxation. The Hibiscus Spa provides rejuvenating massages, aromatherapy, and body scrubs designed to relieve stress and promote wellness. Guests enjoy access to the beach, golf courses, and gourmet dining. Its elegant design, soothing atmosphere, and personalized services create a rejuvenating escape ideal for both couples and families seeking a luxurious coastal experience.
17. Anderson Ocean Club and Spa – Myrtle Beach, SC
Anderson Ocean Club and Spa is a leading destination among spa & wellness resorts in South Carolina. Its Awakening Spa provides deep-tissue massages, detox wraps, and facials using organic ingredients. The oceanfront location allows guests to unwind while listening to calming waves. With spacious suites, fitness facilities, and pools, it offers the perfect mix of relaxation and recreation. This resort’s commitment to comfort, health, and coastal serenity makes it a favorite for wellness enthusiasts.
18. Marina Inn at Grande Dunes – Myrtle Beach, SC
Marina Inn at Grande Dunes is known among spa & wellness resorts in South Carolina for its tranquil setting overlooking the Intracoastal Waterway. The resort offers luxurious spa treatments, including massages, aromatherapy, and skincare therapies. Guests enjoy private beach access, golf, and elegant accommodations. The combination of modern amenities and peaceful surroundings makes it ideal for travelers seeking both comfort and wellness. Its focus on relaxation and natural beauty ensures an unforgettable rejuvenating stay.
19. Francis Marion Hotel – Charleston, SC
The Francis Marion Hotel is a historic gem among spa & wellness resorts in South Carolina. The hotel’s Spa Adagio provides soothing massages, facials, and wellness packages designed to ease tension and restore balance. Located in downtown Charleston, it offers a blend of cultural exploration and relaxation. Guests enjoy charming rooms, fitness access, and fine dining. The elegant ambiance and personalized service make it perfect for travelers seeking comfort, relaxation, and Southern hospitality in one destination.
20. Myrtle Beach Marriott Resort & Spa at Grande Dunes – Myrtle Beach, SC
Myrtle Beach Marriott Resort & Spa at Grande Dunes ranks high among spa & wellness resorts in South Carolina for its ocean-inspired therapies and luxury accommodations. Its Hibiscus Spa features body scrubs, facials, and hot stone massages that refresh the senses. Guests enjoy beach access, pools, and fitness centers for complete relaxation. With its focus on holistic wellness and scenic views, it provides a perfect environment for rejuvenation and an unforgettable coastal spa experience.
21. Hilton Myrtle Beach Resort – Myrtle Beach, SC
Hilton Myrtle Beach Resort is a beachfront haven among spa & wellness resorts in South Carolina. The Spa 33 offers massages, wraps, and relaxation treatments using natural oils and minerals. Guests enjoy yoga sessions, fitness centers, and ocean views that enhance wellness and peace. The resort’s modern amenities, coastal charm, and excellent service make it a top choice for travelers looking to combine beachside leisure with a revitalizing wellness retreat in a serene setting.
22. The Beach Club at Charleston Harbor Resort – Mount Pleasant, SC
The Beach Club at Charleston Harbor Resort is one of the top spa & wellness resorts in South Carolina for its luxurious Estuary Spa. The spa specializes in marine-based treatments, massages, and facials that promote total relaxation. Guests can enjoy waterfront dining, private pools, and panoramic harbor views. Its combination of coastal beauty, Southern charm, and personalized wellness services makes it ideal for those seeking a balanced, refreshing escape in the heart of Charleston Harbor.
23. The Breakers Resort – Myrtle Beach, SC
The Breakers Resort is a well-known destination among spa & wellness resorts in South Carolina, offering oceanfront relaxation and professional spa services. Guests can enjoy deep-tissue massages, skin treatments, and aromatherapy sessions designed to rejuvenate both body and mind. With multiple pools, fitness facilities, and scenic ocean views, it provides the perfect mix of leisure and wellness. Its family-friendly atmosphere and peaceful setting make it one of the most relaxing resorts along the Myrtle Beach coast.
24. HarbourView Inn – Charleston, SC
HarbourView Inn is a boutique-style retreat among spa & wellness resorts in South Carolina. Although smaller in scale, it focuses on wellness partnerships with nearby spas, offering guests customized massages and skincare sessions. The elegant accommodations and stunning harbor views create a serene environment for relaxation. Located in downtown Charleston, guests can enjoy wellness and culture in one stay. Its peaceful charm and attention to detail make it a favorite for those seeking mindful rejuvenation.
25. Planters Inn – Charleston, SC
Planters Inn is a luxury landmark among spa & wellness resorts in South Carolina. Nestled in the heart of Charleston, it partners with nearby wellness centers to offer exclusive spa experiences, including massages, facials, and aromatherapy treatments. The elegant suites, lush courtyards, and fine dining enhance relaxation. Guests experience Southern charm combined with tranquil comfort. It’s the perfect choice for travelers looking to rejuvenate while enjoying Charleston’s hospitality, style, and personalized wellness-focused experiences in one location.
26. North Beach Resort & Villas – North Myrtle Beach, SC
North Beach Resort & Villas is among the finest spa & wellness resorts in South Carolina. Its Cinzia Spa provides extensive wellness treatments such as hydrotherapy, massages, facials, and detox therapies. Guests can also participate in yoga or fitness sessions. The resort’s oceanfront setting and luxurious villas offer a peaceful environment for complete relaxation. Its dedication to health, beauty, and tranquility makes it one of the most sought-after destinations for rejuvenation on South Carolina’s coast.
27. Tides Folly Beach Hotel – Folly Beach, SC
Tides Folly Beach Hotel stands among coastal spa & wellness resorts in South Carolina for its relaxing beachfront environment. While offering partnerships with local spas, guests enjoy wellness-inspired activities like yoga on the beach, guided meditation, and oceanfront dining. The sound of the waves creates a natural calming effect, perfect for stress relief. Its casual yet elegant style makes it ideal for those who want a rejuvenating seaside experience paired with natural wellness vibes.
28. 21c Museum Hotel – Charleston, SC
21c Museum Hotel is one of the most unique spa & wellness resorts in South Carolina, combining art, culture, and relaxation. Guests enjoy access to in-room spa services, massages, and wellness therapies in an inspiring artistic setting. The hotel’s contemporary design, local cuisine, and creative ambiance promote mindfulness and comfort. Perfect for travelers who appreciate both luxury and culture, it offers a peaceful and inspiring wellness escape within the vibrant heart of downtown Charleston.
29. The Vendue Hotel – Charleston, SC
The Vendue Hotel is an artistic gem among spa & wellness resorts in South Carolina. Located in Charleston’s historic district, it offers partnerships with nearby wellness spas for guests to enjoy massages, facials, and holistic therapies. The hotel’s artistic interiors and rooftop views enhance relaxation. Combining art, comfort, and wellness, it provides a creative and peaceful environment for rest and renewal. It’s ideal for visitors who value culture, relaxation, and personalized luxury experiences.
30. Litchfield Beach & Golf Resort – Pawleys Island, SC
Litchfield Beach & Golf Resort is a peaceful coastal getaway among spa & wellness resorts in South Carolina. Guests enjoy access to relaxing massages, yoga sessions, and fitness programs designed to promote overall health. Surrounded by nature, the resort provides a serene atmosphere perfect for unwinding. With beach access, golf, and comfortable villas, it offers a well-rounded experience that balances leisure and wellness. It’s a perfect choice for travelers seeking rest and rejuvenation near Myrtle Beach.
31. The Governor’s House Inn – Charleston, SC
The Governor’s House Inn is a charming retreat among spa & wellness resorts in South Carolina. Located in a historic mansion, it offers intimate spa services through local wellness providers. Guests can enjoy therapeutic massages, aromatherapy, and relaxation sessions in elegant surroundings. The cozy rooms, historic décor, and personalized attention create a tranquil experience. It’s an ideal destination for guests seeking both cultural exploration and quiet rejuvenation in the timeless beauty of downtown Charleston.
32. The Inlet Sports Lodge – Murrells Inlet, SC
The Inlet Sports Lodge is a hidden gem among spa & wellness resorts in South Carolina, perfect for guests seeking relaxation and adventure. While the lodge focuses on outdoor wellness like fishing, kayaking, and golf, nearby spas offer massage and skincare treatments to complement the experience. Guests enjoy comfortable suites, fine dining, and a peaceful atmosphere. Its balance of outdoor activity and restorative relaxation makes it a refreshing coastal retreat for health and wellness seekers.
33. Sea Pines Resort – Hilton Head Island, SC
Sea Pines Resort ranks among the most beloved spa & wellness resorts in South Carolina. Its spa offers a wide selection of wellness treatments including massages, facials, and fitness programs tailored to guest needs. Surrounded by beaches and pine forests, it provides a peaceful escape from daily stress. Guests can enjoy biking, golf, and yoga sessions along scenic trails. The combination of nature, comfort, and professional care makes it a premier destination for total rejuvenation.
34. Anderson Ocean Spa Suites – Myrtle Beach, SC
Anderson Ocean Spa Suites is an elegant choice among spa & wellness resorts in South Carolina. It features spacious suites and access to the renowned Awakening Spa, where guests can enjoy rejuvenating massages, facials, and holistic therapies. The oceanfront location enhances the calming effect of every treatment. Visitors can unwind with wellness programs, fitness classes, and ocean walks. This resort’s tranquil setting and dedication to well-being make it perfect for a luxurious, health-focused getaway.
35. The Willcox – Aiken, SC
The Willcox is one of the most historic spa & wellness resorts in South Carolina, offering timeless elegance and personalized wellness experiences. Its spa features organic facials, massages, and body scrubs designed for deep relaxation. Guests can enjoy fitness sessions, fine dining, and cozy suites. The hotel’s old-world charm, warm service, and commitment to wellness create a peaceful sanctuary. It’s a top choice for travelers seeking refined luxury, health, and tranquility in a historic Southern setting.
Reasons Why They Are The Top Spa and Wellness Resorts in South Carolina
- Exceptional spa facilities that offer a variety of massages, facials, and holistic treatments tailored to each guest’s needs.
- Breathtaking natural surroundings, from coastal beaches to scenic mountain landscapes that enhance relaxation and peace.
- Expertly trained therapists who deliver world-class care and use organic, high-quality products.
- Luxurious accommodations designed for comfort, serenity, and privacy, perfect for a rejuvenating getaway.
- Integration of fitness, yoga, and meditation programs that promote overall physical and mental well-being.
- Award-winning restaurants that focus on healthy, gourmet cuisine made with locally sourced ingredients.
- Unique wellness packages combining spa therapy, adventure, and relaxation to suit every traveler’s lifestyle.
- Exceptional Southern hospitality and attention to detail that ensure every guest feels refreshed and cared for.
Reasons Why You Should Visit These Top Spa and Wellness Resorts in South Carolina
- To escape from daily stress and immerse yourself in a peaceful, healing environment surrounded by nature.
- To experience holistic treatments that restore balance and rejuvenate both body and mind.
- To enjoy luxury amenities, including pools, saunas, yoga studios, and fitness centers.
- To explore South Carolina’s rich cultural heritage while relaxing in world-class resorts.
- To indulge in personalized wellness programs that help improve sleep, energy, and mindfulness.
- To reconnect with loved ones or enjoy quiet solitude in a setting designed for total relaxation.
- To benefit from expert care that blends traditional techniques with modern wellness innovations.
Conclusion
The top spa & wellness resorts in South Carolina provide the perfect opportunity to slow down, breathe deeply, and focus on personal well-being. Whether you prefer the serene beaches of Hilton Head Island, the artistic atmosphere of Charleston, or the tranquil mountains of the Upstate, each destination offers a unique path to relaxation and renewal. With world-class treatments, gourmet dining, and unmatched hospitality, these resorts promise a memorable experience that leaves you refreshed, inspired, and truly at peace.