Bells HardingstoneMississippi is home to some of the most relaxing and luxurious spa and wellness resorts in the southern United States. From the coastal beauty of Biloxi to the historic charm of Natchez and Greenwood, these resorts offer guests a blend of tranquility, luxury, and Southern hospitality. The top spa and wellness resorts in Mississippi provide soothing massages, holistic therapies, and modern wellness facilities designed to restore both body and mind, making them ideal for relaxation, romance, and rejuvenation.
Top 30 Spa and Wellness Resorts in Mississippi
1. Beau Rivage Resort & Casino, Biloxi, MS
Beau Rivage Resort & Casino stands as one of the most luxurious spa & wellness resorts in Mississippi, offering world-class spa treatments in a peaceful coastal setting. Guests enjoy massages, facials, and body therapies tailored for full relaxation. Its serene environment, professional staff, and stunning Gulf views make it a favorite destination for both tourists and locals seeking wellness, balance, and rejuvenation along the Mississippi Gulf Coast.
2. IP Casino Resort & Spa, Biloxi, MS
IP Casino Resort & Spa is among the most popular spa & wellness resorts in Mississippi, known for its relaxing atmosphere and extensive wellness amenities. The spa features therapeutic massages, body wraps, facials, and aromatherapy designed to refresh the mind and body. Its waterfront location and elegant interiors create an ideal space for ultimate relaxation, making it one of the best choices for spa lovers visiting Biloxi or the Gulf Coast region.
3. Hard Rock Hotel & Casino Biloxi, Biloxi, MS
Hard Rock Hotel & Casino Biloxi hosts the famous Rock Spa, offering signature massages, steam therapy, and beauty treatments. As one of the top spa & wellness resorts in Mississippi, it combines the excitement of entertainment with tranquil wellness services. Guests enjoy luxury spa experiences in a music-themed setting that encourages rest and rejuvenation. The resort’s Gulf view and vibrant energy make it an iconic relaxation spot in Mississippi.
4. Palace Casino Resort, Biloxi, MS
Palace Casino Resort provides a peaceful retreat among the top spa & wellness resorts in Mississippi. It features a full-service spa with deep tissue massages, facials, and rejuvenation therapies that focus on total body wellness. Its smoke-free environment and beautiful coastal location make it especially appealing to health-conscious guests seeking calm and comfort while still enjoying resort amenities and oceanfront views.
5. Golden Nugget Biloxi Casino & Resort, Biloxi, MS
Golden Nugget Biloxi Casino & Resort offers luxurious spa facilities with body treatments, facials, and hot stone massages. It is one of the most loved spa & wellness resorts in Mississippi because it blends relaxation with entertainment. The professional therapists and calming ambiance provide guests with a truly refreshing experience. Its location along the Gulf Coast adds a beautiful coastal charm that enhances every wellness session.
6. Harrah’s Gulf Coast, Biloxi, MS
Harrah’s Gulf Coast is a coastal sanctuary for travelers who appreciate relaxation and style. As one of the best spa & wellness resorts in Mississippi, it offers signature massages, facials, and a wellness lounge designed for complete serenity. Guests can indulge in therapeutic treatments before enjoying the oceanfront pool and resort amenities. The tranquil design and attentive service make Harrah’s an excellent choice for relaxation and health-focused stays.
7. Sheraton Flowood The Refuge Hotel & Conference Center, Flowood, MS
Sheraton Flowood The Refuge Hotel is a refined destination among spa & wellness resorts in Mississippi, featuring modern spa facilities, body treatments, and yoga-friendly environments. Located in Flowood, it blends business comfort with leisure relaxation, making it perfect for travelers seeking rest after conferences or meetings. The resort’s natural surroundings and stylish atmosphere create an exceptional space for health, recovery, and peace of mind.
8. The Westin Jackson, Jackson, MS
The Westin Jackson is home to Soul Spa, one of the most relaxing spa experiences in Mississippi. It stands out among the top spa & wellness resorts in Mississippi for its holistic treatments and luxury amenities. Guests enjoy customized massages, facials, and wellness therapies aimed at restoring physical and mental balance. Its urban yet serene atmosphere makes it a refreshing retreat in the capital city of Jackson.
9. The Alluvian Hotel & Spa, Greenwood, MS
The Alluvian Hotel & Spa in Greenwood offers a unique Southern wellness experience. Known for its Sweet Tea and Magnolia-inspired treatments, it’s one of the top spa & wellness resorts in Mississippi’s Delta region. Guests enjoy personalized services like massages, body scrubs, and luxury facials. The Alluvian’s boutique charm, elegant design, and attention to detail create a truly soothing environment for relaxation and renewal.
10. Pearl River Resort, Choctaw, MS
Pearl River Resort is a comprehensive destination that features world-class casino entertainment, golf, and wellness facilities. It ranks among the leading spa & wellness resorts in Mississippi due to its full-service spa, body therapies, and indigenous-inspired treatments. Surrounded by nature and Choctaw heritage, the resort offers a unique blend of culture, comfort, and rejuvenation, making it ideal for guests who want more than just relaxation.
11. Hollywood Casino Gulf Coast, Bay St. Louis, MS
Hollywood Casino Gulf Coast combines classic resort comfort with rejuvenating spa amenities. As one of the top spa & wellness resorts in Mississippi, it offers relaxing treatments, hydrotherapy sessions, and fitness options for guests who prioritize wellness. Its Gulf view and warm hospitality make it a great coastal retreat. Visitors can unwind after exploring the area’s beaches and attractions, making every stay memorable and refreshing.
12. Scarlet Pearl Casino Resort, D’Iberville, MS
Scarlet Pearl Casino Resort provides guests with a modern wellness experience in a luxurious setting. It’s one of the best spa & wellness resorts in Mississippi, featuring massage services, spa suites, and fitness facilities designed for ultimate rejuvenation. The resort’s elegant design and focus on guest comfort create a peaceful escape, while its location near Biloxi’s attractions adds convenience for visitors seeking both excitement and rest.
13. Harlow’s Casino Resort & Spa, Greenville, MS
Harlow’s Casino Resort & Spa in Greenville is a hidden gem among spa & wellness resorts in Mississippi. It features a tranquil spa environment offering massages, facials, and rejuvenation therapies for guests seeking peace and relaxation. The friendly staff and quiet Delta setting provide a true escape from daily stress, making Harlow’s an excellent choice for travelers looking for wellness with Southern hospitality.
14. Silver Star Hotel & Casino, Choctaw, MS
Silver Star Hotel & Casino offers a refined wellness experience within the Pearl River Resort complex. It’s one of the leading spa & wellness resorts in Mississippi, known for its professional spa staff, soothing treatments, and high-quality amenities. The property blends luxury with cultural warmth, offering guests a balance of relaxation and excitement that makes every visit both refreshing and memorable.
15. Fairview Inn, Jackson, MS
Fairview Inn is a charming boutique retreat offering relaxation and comfort in the heart of Jackson. As one of the top spa & wellness resorts in Mississippi, it provides spa tubs, massage treatments, and cozy accommodations for a peaceful stay. Its historic charm and personalized service create a home-like environment where guests can unwind, making it an ideal destination for those who value comfort, privacy, and rejuvenation.
16. White House Hotel, Biloxi, MS
White House Hotel is a coastal gem among spa & wellness resorts in Mississippi, offering classic Southern charm with modern relaxation amenities. Guests can enjoy soothing spa services, yoga sessions, and ocean-view relaxation spaces. Its serene setting, historic design, and proximity to Biloxi Beach make it a perfect getaway for wellness seekers who crave peace, style, and rejuvenation in a luxurious yet homely environment.
17. Centennial Plaza Resort, Gulfport, MS
Centennial Plaza Resort is known for combining elegance with comfort, featuring spa-inspired relaxation areas and wellness-focused hospitality. As one of the best spa & wellness resorts in Mississippi, it offers massages, fitness access, and serene outdoor spaces surrounded by coastal beauty. Its calm environment and professional service make it ideal for travelers who want to refresh their mind and body near the Gulf Coast.
18. Margaritaville Resort, Biloxi, MS
Margaritaville Resort Biloxi provides a fun-filled escape while offering spa-style relaxation. It stands among the most vibrant spa & wellness resorts in Mississippi for guests seeking both entertainment and wellness. The resort’s tropical-inspired atmosphere, rejuvenating massage services, and scenic Gulf views create a perfect balance between excitement and calm, appealing to families and couples alike who value health and leisure.
19. Golden Moon Hotel & Casino, Choctaw, MS
Golden Moon Hotel & Casino offers a complete relaxation experience with its spa, fitness center, and elegant suites. As part of Pearl River Resort, it’s one of the top spa & wellness resorts in Mississippi that blends luxury with cultural charm. Guests can unwind with body treatments, facials, and hydrotherapy sessions while enjoying premium amenities and a peaceful natural setting.
20. Ocean Club at Biloxi, Biloxi, MS
Ocean Club at Biloxi provides a quiet beachfront escape for those seeking spa-inspired tranquility. Recognized among the top spa & wellness resorts in Mississippi, it offers personalized wellness services, private accommodations, and fitness facilities. Guests love the ocean views, peaceful ambiance, and exclusive atmosphere that make it a relaxing and rejuvenating coastal retreat.
21. Bay Town Inn, Bay St. Louis, MS
Bay Town Inn is a boutique wellness getaway offering comfort, personalized care, and peaceful coastal charm. It’s one of the most intimate spa & wellness resorts in Mississippi, known for massages, pool relaxation, and stress-free stays. Guests enjoy the warm hospitality and coastal views that make it an excellent choice for those seeking a calm and healing environment near the Gulf.
22. Hotel Legends, Biloxi, MS
Hotel Legends provides a modern yet elegant approach to wellness and comfort. As one of the standout spa & wellness resorts in Mississippi, it features spacious rooms, relaxation lounges, and in-room spa services. The resort’s stylish design, combined with its focus on guest serenity, creates an inviting space for relaxation and rejuvenation in the heart of Biloxi.
23. Hilton Garden Inn, Olive Branch, MS
Hilton Garden Inn in Olive Branch is a peaceful suburban retreat offering spa-inspired amenities and fitness options. Among the spa & wellness resorts in Mississippi, it’s known for comfort, friendly service, and a calm environment perfect for business or leisure travelers. Guests appreciate its well-equipped wellness spaces and quiet surroundings, ideal for recharging both body and mind.
24. The Threefoot Hotel, Meridian, MS
The Threefoot Hotel combines historical elegance with modern wellness offerings. It’s one of the most charming spa & wellness resorts in Mississippi, featuring spa treatments, yoga-friendly rooms, and serene spaces for rest. Guests enjoy the blend of art deco style and calm atmosphere, making it a perfect spot for those seeking culture and relaxation together.
25. The Roost Hotel, Ocean Springs, MS
The Roost Hotel is a boutique retreat surrounded by nature and coastal charm. It stands out among spa & wellness resorts in Mississippi for its intimate setting, holistic wellness approach, and relaxing décor. Guests enjoy massages, aromatherapy, and peaceful walks through the nearby beach area, making it an ideal destination for serenity and renewal.
26. The Inn at Ocean Springs, Ocean Springs, MS
The Inn at Ocean Springs offers a tranquil setting ideal for rejuvenation and calm. As one of the top spa & wellness resorts in Mississippi, it emphasizes relaxation through massages, wellness programs, and peaceful accommodations. Guests love the artistic and cozy atmosphere, which makes it perfect for couples and travelers seeking quiet coastal wellness experiences.
27. Oxford Spa & Retreat, Oxford, MS
Oxford Spa & Retreat provides a countryside escape where guests enjoy body treatments, yoga, and meditation sessions. It’s among the most rejuvenating spa & wellness resorts in Mississippi, known for its peaceful setting and professional wellness services. The retreat offers an ideal mix of nature, relaxation, and hospitality, allowing visitors to unwind completely in a refreshing environment.
28. Monmouth Historic Inn & Gardens, Natchez, MS
Monmouth Historic Inn & Gardens blends history with relaxation, offering guests spa-inspired amenities and serene gardens. It is one of the most elegant spa & wellness resorts in Mississippi, known for personalized service, massages, and peaceful ambiance. The combination of Southern heritage and modern wellness experiences makes it a favorite for romantic and rejuvenating getaways.
29. Dunleith Historic Inn, Natchez, MS
Dunleith Historic Inn provides a luxurious yet calm atmosphere ideal for rest and relaxation. As one of the top spa & wellness resorts in Mississippi, it offers guests therapeutic treatments, wellness dining, and quiet outdoor spaces. Its historic architecture and serene gardens make it a unique retreat for travelers who seek beauty, history, and holistic well-being in one location.
30. Hilton Jackson, Jackson, MS
Hilton Jackson delivers a refined urban wellness experience, offering spa-inspired amenities, fitness access, and comfortable rooms. It ranks among the best spa & wellness resorts in Mississippi for travelers who appreciate both luxury and health. Guests enjoy in-room massages, relaxation lounges, and easy access to Jackson’s attractions, making it a perfect blend of business comfort and personal rejuvenation.
Reasons Why They Are The Top Spa and Wellness Resorts in Mississippi
- They offer world-class spa treatments including massages, facials, aromatherapy, and hydrotherapy.
- Their locations combine natural beauty with peaceful surroundings perfect for relaxation.
- Most resorts feature modern wellness centers equipped with professional therapists and advanced facilities.
- They provide a mix of luxury accommodations, fine dining, and relaxation amenities.
- Their professional staff ensure personalized wellness experiences tailored to each guest’s needs.
- Many resorts include fitness centers, yoga programs, and meditation spaces for full-body wellness.
- Their coastal and countryside settings enhance the natural healing experience.
- Consistent positive guest reviews highlight their exceptional service, comfort, and serene atmosphere.
Reasons Why You Should Visit These Top Spa and Wellness Resorts in Mississippi
- They offer an escape from stress and promote total mental and physical relaxation.
- Guests can enjoy a combination of luxury, comfort, and health-focused experiences.
- The resorts’ scenic locations create the perfect environment for rejuvenation and reflection.
- Their treatments use high-quality natural ingredients and skilled techniques.
- Each visit provides opportunities for self-care, healing, and personal renewal.
- Many resorts feature romantic settings, making them ideal for couples’ getaways.
- They deliver authentic Southern hospitality alongside world-class wellness services.
Conclusion
The top spa and wellness resorts in Mississippi are more than just places to unwind—they are sanctuaries designed to restore balance, energy, and peace. Whether you choose the luxurious coastal resorts in Biloxi, the tranquil countryside retreats in Greenwood, or the historic wellness inns in Natchez, you’ll find unmatched care and comfort. These resorts reflect Mississippi’s growing reputation as a destination for relaxation and well-being, offering experiences that refresh the body, calm the mind, and renew the spirit.