Missouri is home to some of the most captivating destinations for relaxation, rejuvenation, and wellness. The top spa and wellness resorts in Missouri combine natural beauty, world-class hospitality, and therapeutic treatments designed to restore balance and peace. From the scenic Ozark Mountains to the vibrant cities of St. Louis and Kansas City, these resorts offer guests a blend of luxury, tranquility, and personalized care. Whether seeking a romantic getaway or a solo retreat, Missouri’s spa and wellness resorts provide the ideal setting for holistic renewal and serenity.
Top 30 Spa and Wellness Resorts in Missouri
1. Chateau on the Lake Resort Spa & Convention Center – Branson, Missouri
Chateau on the Lake Resort is one of the finest spa & wellness resorts in Missouri, located in Branson with a scenic view of Table Rock Lake. The resort offers a 14,000-square-foot spa featuring Roman baths, steam rooms, and private treatment areas. Guests enjoy holistic therapies, facials, and massages that promote deep relaxation. Its blend of luxury, lakefront setting, and top-tier wellness services make it a perfect destination for rejuvenation and leisure.
2. Cedar Creek Spa & Salon at Big Cedar Lodge – Ridgedale, Missouri
Big Cedar Lodge is home to Cedar Creek Spa & Salon, a premier spa & wellness resort in Missouri surrounded by the Ozark Mountains. It features a grotto pool, stone fireplaces, and treatment rooms designed for peace and tranquility. The spa’s luxurious ambiance and nature-inspired therapies help guests achieve mental and physical balance. Its award-winning services and serene environment make it a top destination for health-conscious travelers.
3. The Elms Hotel & Spa – Excelsior Springs, Missouri
The Elms Hotel & Spa is a historic retreat that stands out among spa & wellness resorts in Missouri. Located in Excelsior Springs, it offers therapeutic mineral baths, massages, and a healing grotto. The spa combines old-world charm with modern wellness treatments to create a restorative experience. Its legacy as a healing destination makes it an ideal choice for those seeking both history and relaxation.
4. Spa Shiki at The Lodge of Four Seasons – Lake Ozark, Missouri
Spa Shiki, located within The Lodge of Four Seasons, is among the most serene spa & wellness resorts in Missouri. It embraces Eastern-inspired wellness techniques and offers massages, aromatherapy, and holistic healing. The spa’s Japanese garden setting and tranquil atmosphere provide a deep sense of calm. Guests can unwind by the lake and enjoy full-body rejuvenation in a resort known for luxury and balance.
5. Four Seasons Hotel Spa – St. Louis, Missouri
The Four Seasons Hotel in St. Louis offers an elegant urban retreat, ranking high among spa & wellness resorts in Missouri. The spa features steam rooms, saunas, and hydrotherapy treatments with a view of the Gateway Arch. Personalized wellness programs and premium massages provide a complete rejuvenating experience. Its luxurious setting and expert therapists make it ideal for business travelers and relaxation seekers alike.
6. Ameristar Casino Resort Spa – St. Charles, Missouri
Ameristar Casino Resort Spa in St. Charles combines entertainment with wellness. As one of the premier spa & wellness resorts in Missouri, it offers hydrotherapy, facials, and body treatments in a sophisticated environment. Guests can enjoy casino entertainment alongside a calming spa escape. Its combination of excitement and relaxation makes it a unique all-in-one destination for couples and groups.
7. Margaritaville Lake Resort – Osage Beach, Missouri
Margaritaville Lake Resort offers a perfect blend of relaxation and lake adventure, placing it among the top spa & wellness resorts in Missouri. Located at Lake of the Ozarks, it provides soothing spa treatments, wellness programs, and lakeside serenity. Guests can unwind with massages and facials while enjoying water views. Its laid-back atmosphere and modern amenities create a rejuvenating experience for all visitors.
8. The Spa at Old Kinderhook Resort – Camdenton, Missouri
The Spa at Old Kinderhook Resort in Camdenton is a favorite among spa & wellness resorts in Missouri. Nestled by the Lake of the Ozarks, it offers specialized massages, skincare, and nail treatments. The peaceful lakeside ambiance enhances relaxation and wellness. The resort’s friendly service, luxurious accommodations, and tranquil setting make it a sought-after retreat for both locals and travelers.
9. The Spa at Riverbend Retreat – Steelville, Missouri
Riverbend Retreat is a quiet hideaway that deserves recognition among spa & wellness resorts in Missouri. Surrounded by nature, it offers aromatherapy, massages, and yoga sessions designed for stress relief. Guests enjoy personal wellness plans in a peaceful, rural setting. The retreat’s focus on holistic healing and connection with nature makes it perfect for those seeking true rejuvenation away from city life.
10. Stonewater Cove Resort & Club – Shell Knob, Missouri
Stonewater Cove Resort & Club is an exclusive lakeside property considered one of the finest spa & wellness resorts in Missouri. Guests enjoy outdoor activities alongside spa treatments like deep-tissue massages and hydrotherapy. The resort’s secluded location on Table Rock Lake provides tranquility and privacy. Its combination of nature, adventure, and luxury spa experiences creates an unforgettable wellness escape.
11. River Hills Retreat & Spa – Rocheport, Missouri
River Hills Retreat & Spa, located near the Missouri River, is one of the coziest spa & wellness resorts in Missouri. It focuses on mindfulness, yoga, and personalized spa sessions. The rustic yet refined accommodations and scenic vineyards add to its charm. Guests experience complete relaxation surrounded by nature and fine wine country ambiance. Its dedication to holistic wellness makes it a hidden gem for peaceful retreats.
12. Camden on the Lake Resort Spa – Lake Ozark, Missouri
Camden on the Lake Resort features a full-service spa that promotes rejuvenation through massages, skincare, and aromatherapy. Recognized among the best spa & wellness resorts in Missouri, it blends lakefront luxury with professional spa care. Guests can enjoy lakeside dining and wellness experiences all in one place. Its balance of leisure, entertainment, and relaxation keeps it a favorite choice for wellness seekers.
13. The Spa at The Wildwood Hotel – Wildwood, Missouri
The Spa at The Wildwood Hotel offers a boutique wellness experience and stands among quality spa & wellness resorts in Missouri. Located near scenic trails, it provides massages, facials, and body wraps in a peaceful environment. Guests can pair spa relaxation with outdoor adventures. Its small-scale, personalized service and comfortable ambiance make it ideal for intimate relaxation escapes.
14. Sycamore Creek Family Ranch & Wellness Center – Branson, Missouri
Sycamore Creek Family Ranch is a wellness-centered retreat recognized among spa & wellness resorts in Missouri. It focuses on family-oriented wellness, yoga, and massage therapy surrounded by Ozark beauty. Guests enjoy natural scenery, meditation sessions, and local hospitality. Its wholesome approach to relaxation and connection with nature make it a unique destination for wellness enthusiasts.
15. Inn at Hermannhof Spa Suites – Hermann, Missouri
The Inn at Hermannhof in the charming town of Hermann features luxurious spa suites and personalized services, making it one of the most intimate spa & wellness resorts in Missouri. Guests enjoy massages, aromatherapy, and wine-inspired treatments. Its cozy design, historic surroundings, and focus on relaxation create a romantic and rejuvenating experience ideal for couples or solo travelers seeking tranquility.
16. Spa 54 at Hotel Vandivort – Springfield, Missouri
Spa 54 at Hotel Vandivort is a modern wellness escape known for its elegant design and exceptional treatments. As one of the leading spa & wellness resorts in Missouri, it offers customized massages, skincare therapies, and relaxation lounges. Located in downtown Springfield, the spa combines urban sophistication with tranquility. Guests appreciate its soothing ambiance, professional therapists, and focus on holistic rejuvenation, making it a preferred choice for both locals and visitors.
17. Still Waters Resort & Spa – Branson, Missouri
Still Waters Resort offers a relaxing spa experience near Table Rock Lake, making it a standout among spa & wellness resorts in Missouri. Guests enjoy massages, facials, and stress-relief treatments surrounded by breathtaking lake views. The resort’s peaceful atmosphere and wide range of recreational activities balance relaxation and adventure. Its focus on family-friendly wellness and lakeside tranquility attracts those seeking harmony and comfort.
18. The Spa at Tan-Tar-A Estates – Osage Beach, Missouri
The Spa at Tan-Tar-A Estates offers an exclusive blend of relaxation and sophistication within Lake of the Ozarks. Recognized as one of the top spa & wellness resorts in Missouri, it provides massages, facials, and body wraps designed to rejuvenate the mind and body. The scenic lake backdrop, combined with attentive service and luxurious amenities, ensures a revitalizing experience for every guest.
19. The Spa at The Raphael Hotel – Kansas City, Missouri
The Raphael Hotel offers a boutique spa experience in the heart of Kansas City. This elegant destination is among the refined spa & wellness resorts in Missouri, offering signature massages, aromatherapy, and wellness therapies. Guests enjoy personalized care in an intimate, sophisticated atmosphere. The hotel’s historical charm and commitment to relaxation make it a perfect getaway for travelers seeking both comfort and culture.
20. Lakeview Resort Spa – Sunrise Beach, Missouri
Lakeview Resort Spa, located on the Lake of the Ozarks, provides a calm and intimate retreat ideal for relaxation. Known as one of the top-rated spa & wellness resorts in Missouri, it offers therapeutic massages, facials, and fitness programs. The tranquil lake setting enhances every wellness treatment, allowing guests to unwind completely. Its warm hospitality and serene surroundings make it a haven for peaceful rejuvenation.
21. Serenity Valley Resort – Fulton, Missouri
Serenity Valley Resort lives up to its name as a serene escape among spa & wellness resorts in Missouri. Surrounded by lakes and wooded landscapes, it offers yoga sessions, meditation, and personalized wellness therapies. Guests can stay in cozy cabins designed for comfort and reflection. Its nature-centered wellness programs and quiet charm make it a perfect destination for stress relief and relaxation.
22. Paradise Point Resort & Spa – Hollister, Missouri
Paradise Point Resort & Spa provides luxury and leisure within the scenic Ozark Mountains. As one of the most peaceful spa & wellness resorts in Missouri, it offers massage therapies, body scrubs, and spa packages for couples and families. The resort’s breathtaking views and calm surroundings enhance every treatment. Its commitment to total well-being makes it a favorite destination for nature and wellness lovers alike.
23. Seven Springs Winery & Spa – Linn Creek, Missouri
Seven Springs Winery & Spa combines fine wine with wellness, earning its place among the top spa & wellness resorts in Missouri. Guests enjoy vineyard views while indulging in massages, body wraps, and relaxation sessions. The resort’s serene vineyard environment encourages mindfulness and rest. Its unique mix of relaxation, wine, and nature creates a memorable and refreshing experience for all visitors.
24. The Spa at St. Charles Historic Inn – St. Charles, Missouri
The Spa at St. Charles Historic Inn is known for personalized treatments and historic charm. As one of the most delightful spa & wellness resorts in Missouri, it offers massages, facials, and natural body therapies. Guests enjoy the cozy, intimate setting that reflects the town’s old-world elegance. The inn’s focus on relaxation and heritage creates a comforting and rejuvenating atmosphere for guests.
25. Willow Spring Mercantile & Spa – Excelsior Springs, Missouri
Willow Spring Mercantile & Spa is a charming destination recognized among spa & wellness resorts in Missouri for its personalized approach to wellness. Guests enjoy therapeutic massages, aromatherapy, and herbal skincare treatments. The spa’s cozy ambiance and friendly service provide a home-like relaxation experience. Its combination of small-town hospitality and professional care makes it ideal for peaceful retreats.
26. Bluff Dwellers Wellness Retreat – Noel, Missouri
Bluff Dwellers Wellness Retreat is one of the most secluded spa & wellness resorts in Missouri. Set among the beautiful Ozark cliffs, it offers healing massages, yoga, and meditation sessions. Guests reconnect with nature while enjoying peaceful accommodations. The retreat’s quiet charm and nature-inspired programs create a rejuvenating environment perfect for escaping everyday stress.
27. The Ozark Mountain Resort Spa – Kimberling City, Missouri
The Ozark Mountain Resort Spa stands out as a top family-friendly destination among spa & wellness resorts in Missouri. Nestled near Table Rock Lake, it offers wellness services including massages, saunas, and outdoor hot tubs. Guests can enjoy both recreation and relaxation surrounded by mountain scenery. Its balance of natural beauty and restorative care makes it ideal for families and couples alike.
28. Hidden Valley Retreat & Spa – Eureka, Missouri
Hidden Valley Retreat & Spa is a peaceful haven that embodies tranquility among spa & wellness resorts in Missouri. Located near the Hidden Valley nature area, it offers holistic treatments, aromatherapy, and guided meditation. Guests appreciate its privacy, cozy cabins, and calming atmosphere. The retreat’s focus on mindfulness and inner peace makes it an exceptional place for complete rejuvenation.
29. Spa at Sycamore Ridge – Springfield, Missouri
Spa at Sycamore Ridge is one of the finest boutique spa & wellness resorts in Missouri. It provides rejuvenating facials, massages, and relaxation therapies in a calm rural setting. The spa’s experienced staff and attention to detail ensure personalized wellness experiences. Guests enjoy peace, comfort, and natural beauty, making it a relaxing getaway for both locals and travelers seeking tranquility.
30. Harmony Hill Spa Retreat – Columbia, Missouri
Harmony Hill Spa Retreat is a holistic destination that completes the list of top spa & wellness resorts in Missouri. Surrounded by rolling hills, it offers yoga, spa therapies, and organic treatments focused on full-body renewal. Guests appreciate its farm-to-table dining and eco-friendly wellness approach. Its emphasis on inner peace, health, and nature connection makes it one of Missouri’s most rejuvenating escapes.
Reasons Why They Are The Top Spa and Wellness Resorts in Missouri
- Exceptional spa treatments featuring massages, facials, hydrotherapy, and aromatherapy tailored to individual wellness goals.
- Serene locations surrounded by lakes, forests, or mountains that enhance relaxation and mental clarity.
- Professional and certified therapists offering expert care and personalized attention to every guest.
- Luxurious accommodations designed for comfort, privacy, and complete rejuvenation.
- Integration of holistic wellness programs such as yoga, meditation, and mindfulness sessions.
- Modern facilities equipped with saunas, hot tubs, steam rooms, and fitness centers.
- Farm-to-table dining and healthy cuisine options that complement the wellness experience.
- A perfect balance between recreation, leisure, and healing, making them the best spa and wellness destinations in Missouri.
Reasons Why You Should Visit These Top Spa and Wellness Resorts in Missouri
- To escape daily stress and experience mental, physical, and emotional renewal in serene surroundings.
- To indulge in professional wellness therapies designed to relieve tension and promote healing.
- To reconnect with nature through lake views, mountain landscapes, and peaceful outdoor environments.
- To enjoy quality time with loved ones in romantic and relaxing atmospheres.
- To experience luxury amenities, including infinity pools, wellness lounges, and relaxation gardens.
- To participate in wellness workshops and fitness programs that promote long-term health.
- To discover Missouri’s rich hospitality, where comfort and care meet sophistication and tranquility.
Conclusion
The top spa and wellness resorts in Missouri redefine relaxation through luxury, nature, and exceptional care. Whether located by the lake, nestled in the Ozarks, or set in the heart of vibrant cities, each resort promises an unforgettable wellness journey. Guests can unwind, restore balance, and embrace a sense of peace that extends beyond their stay. With their serene ambiance, skilled therapists, and holistic treatments, these resorts make Missouri one of the most rejuvenating wellness destinations in the Midwest.